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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
30/06/2023 |
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Actualizado : |
30/06/2023 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
GIANNITTI, F.; GARCÍA, J. P.; ADAMS, V.; ARMENDANO, J.; BEINGESSER, J.; ROOD, J.; UZAL, F. A. |
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Afiliación : |
FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JORGE P. GARCÍA, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina; VICKI ADAMS, Monash University, Parkville, Victoria, Australia; JOAQUÍN I. ARMENDANO, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina; JULIANN BEINGESSER, California Animal Health and Food Safety Laboratoy, University of California at Davis, San Bernardino, CA; JULIAN I. ROOD, Monash University, Parkville, Victoria, Australia; FRANCISCO A. UZAL, Monash University, Parkville, Victoria, Australia. |
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Título : |
Experimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions. |
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Complemento del título : |
Infectious Disease - Original Article. |
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Fecha de publicación : |
2023 |
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Fuente / Imprenta : |
Veterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669 |
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ISSN : |
0300-9858 (print); 1544-2217 (online). |
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DOI : |
10.1177/03009858231171669 |
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Idioma : |
Inglés |
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Notas : |
Article history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave, San Bernardino, CA 92408, USA. Email: fauzal@ucdavis.edu -- Funding: This work was supported by grant R01 AI056177 from the National Institute of Allergy and Infectious Diseases (NIAID). Research at Monash University was also supported by funding provided by the Australian Research Council to the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics (grant no. CE0562063). -- |
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Contenido : |
ABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 groups. The authors conclude that no specific gross or histologic renal lesions are observed in sheep with experimental acute type D enterotoxemia. © The Author(s) 2023 MenosABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 ... Presentar Todo |
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Palabras claves : |
Clostridium perfringens type D; Enterotoxemia; ETX; Experimental infection; Kidneys; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA; Renal pathology; Sheep. |
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Asunto categoría : |
L10 Genética y mejoramiento animal |
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Marc : |
LEADER 03352naa a2200325 a 4500
001 1064216
005 2023-06-30
008 2023 bl uuuu u00u1 u #d
022 $a0300-9858 (print); 1544-2217 (online).
024 7 $a10.1177/03009858231171669$2DOI
100 1 $aGIANNITTI, F.
245 $aExperimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions.$h[electronic resource]
260 $c2023
500 $aArticle history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave, San Bernardino, CA 92408, USA. Email: fauzal@ucdavis.edu -- Funding: This work was supported by grant R01 AI056177 from the National Institute of Allergy and Infectious Diseases (NIAID). Research at Monash University was also supported by funding provided by the Australian Research Council to the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics (grant no. CE0562063). --
520 $aABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 groups. The authors conclude that no specific gross or histologic renal lesions are observed in sheep with experimental acute type D enterotoxemia. © The Author(s) 2023
653 $aClostridium perfringens type D
653 $aEnterotoxemia
653 $aETX
653 $aExperimental infection
653 $aKidneys
653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA
653 $aRenal pathology
653 $aSheep
700 1 $aGARCÍA, J. P.
700 1 $aADAMS, V.
700 1 $aARMENDANO, J.
700 1 $aBEINGESSER, J.
700 1 $aROOD, J.
700 1 $aUZAL, F. A.
773 $tVeterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669
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INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela; INIA Treinta y Tres. |
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Fecha actual : |
22/09/2020 |
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Actualizado : |
23/09/2020 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
VILLARINO, S.H.; PINTO, P.; DELLA CHIESA, T.; JOBBÁGY, E.G.; STUDDERT, G.A.; BAZZONI, B.; CONTI, G.; RUFINO, M.; ÁLVAREZ, R.; BODDEY , R.; BAYER, C.; DE F CARVALHO, P.C.; FERNÁNDEZ , R.J.; LATTANZI, F.; OESTERHELD , M.; OYHANTÇABAL, W.; PARUELO, J.; PRAVIA, V.; PIÑEIRO, G. |
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Afiliación : |
SEBASTIÁN H. VILLARINO, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina Facultad de Ciencias Agrarias (FCA), Universidad Nacional de Mar del Plata (UNMdP), Argentina.; PRISCILA PINTO, IFEVA-Facultad de Agronomía, Universidad de Buenos Aires, CONICET, Argentina.; TOMAS DELLA CHIESA, IFEVA-Facultad de Agronomía, Universidad de Buenos Aires, CONICET, Argentina.; ESTEBAN G. JOBBÁGY, Grupo de Estudios Ambientales - IMASL, Universidad Nacional de San Luis/ CONICET, Ejército de los Andes 950 (5700), San Luis, Argentina.; GUILLERMO A. STUDDERT, Facultad de Ciencias Agrarias (FCA), Universidad Nacional de Mar del Plata (UNMdP), Argentina.; BRUNO BAZZONI, IFEVA-Facultad de Agronomía, Universidad de Buenos Aires, CONICET, Argentina.; GEORGINA CONTI, Instituto Multidisciplinario de Biología Vegetal, Consejo Nacional de Investigaciones Científicas y Técnicas/ Universidad Nacional de Córdoba, IMBiV (CONICET-UNC), Córdoba, Argentina.; MARIANA RUFINO, Lancaster Environment Centre, Lancaster University, Bailrigg, Lancaster, UK.; ROBERTO ÁLVAREZ, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina Facultad de Agronomía, Universidad de Buenos Aires, Argentina.; ROBERT BODDEY, Embrapa Agrobiologia, Seropédica, Rio de Janeiro, Brazil.; CIMÉLIO BAYER, Faculdade de Agronomia, Universidade Federal do Rio Grande do Sul, Brazil.; PAULO C. DE F. CARVALHO, Faculdade de Agronomia, Universidade Federal do Rio Grande do Sul, Brazil.; ROBERTO J. FERNÁNDEZ, IFEVA-Facultad de Agronomía, Universidad de Buenos Aires, CONICET, Argentina.; FERNANDO A. LATTANZI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARTÍN OESTERHELD, IFEVA-Facultad de Agronomía, Universidad de Buenos Aires, CONICET, Argentina.; WALTER OYHANTÇABAL, Unidad de Sostenibilidad y Cambio Climático, Ministerio de Ganadería, Agricultura y Pesca, Uruguay; JOSÉ PARUELO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay.; MARIA VIRGINIA PRAVIA NIN, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; GERVASIO PIÑEIRO, IFEVA-Facultad de Agronomía, Universidad de Buenos Aires, CONICET, Argentina Departamento de Sistemas Ambientales/ Facultad de Agronomía, Universidad de la República, Uruguay. |
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Título : |
The role of South American grazing lands in mitigating greenhouse gas emissions. A reply to: "Reassessing the role of grazing lands in carbon-balance estimations: Meta-analysis and review", by Viglizzo et al., (2019). (Letter). |
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Fecha de publicación : |
2020 |
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Fuente / Imprenta : |
Science of the Total Environment, 20 October 2020, Volume 740, Article number 140108. Doi: https://doi-org/10.1016/j.scitotenv.2020.140108 |
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DOI : |
10.1016/j.scitotenv.2020.140108 |
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Idioma : |
Inglés |
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Palabras claves : |
ACUMULACION DE CARBONO; CARBON DIOXIDE; CARBON INVENTORY; CARBONO ORGANICO DEL SUELO; DIÓXIDO DE CARBONO; IPCC; MATERIA ORGANICA DEL SUELO; SOIL ORGANIC CARBON; SOIL ORGANIC MATTER MODELLING. |
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Asunto categoría : |
-- |
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Marc : |
LEADER 01511naa a2200445 a 4500
001 1061284
005 2020-09-23
008 2020 bl uuuu u00u1 u #d
024 7 $a10.1016/j.scitotenv.2020.140108$2DOI
100 1 $aVILLARINO, S.H.
245 $aThe role of South American grazing lands in mitigating greenhouse gas emissions. A reply to$b"Reassessing the role of grazing lands in carbon-balance estimations: Meta-analysis and review", by Viglizzo et al., (2019). (Letter).$h[electronic resource]
260 $c2020
653 $aACUMULACION DE CARBONO
653 $aCARBON DIOXIDE
653 $aCARBON INVENTORY
653 $aCARBONO ORGANICO DEL SUELO
653 $aDIÓXIDO DE CARBONO
653 $aIPCC
653 $aMATERIA ORGANICA DEL SUELO
653 $aSOIL ORGANIC CARBON
653 $aSOIL ORGANIC MATTER MODELLING
700 1 $aPINTO, P.
700 1 $aDELLA CHIESA, T.
700 1 $aJOBBÁGY, E.G.
700 1 $aSTUDDERT, G.A.
700 1 $aBAZZONI, B.
700 1 $aCONTI, G.
700 1 $aRUFINO, M.
700 1 $aÁLVAREZ, R.
700 1 $aBODDEY , R.
700 1 $aBAYER, C.
700 1 $aDE F CARVALHO, P.C.
700 1 $aFERNÁNDEZ , R.J.
700 1 $aLATTANZI, F.
700 1 $aOESTERHELD , M.
700 1 $aOYHANTÇABAL, W.
700 1 $aPARUELO, J.
700 1 $aPRAVIA, V.
700 1 $aPIÑEIRO, G.
773 $tScience of the Total Environment, 20 October 2020, Volume 740, Article number 140108. Doi: https://doi-org/10.1016/j.scitotenv.2020.140108
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